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Although Diazepam Rectal Gel is indicated only for intermittent use (see INDICATIONS AND USAGE and DOSAGE AND ADMINISTRATION), if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction or administration of flumazenil, a benzodiazepine antagonist, may precipitate acute withdrawal reactions, including seizures, which can be life-threatening

The WHO reports 1.25 billion tobacco users globally, down from one in three adults in 2000 to one in five now

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Moreover, special processes such as lip release coating and hot-foil applications have gained widespread popularity in modern cigarette production